The Breakthrough

1.

Target the Cancer Stem Cells (CSCs) that lead metastasis, the root cause of cancer.[1]

A subset of tumor cells called cancer stem cells (CSCs) may be responsible for metastasis[2]
Use “Targeted Therapies” that are focused on the identified mutations in the CSCs[3]

2.

Standard therapy may not be effective against CSCs

Traditional non-targeted chemotherapy may decrease primary tumor size but increase the number of CSCs[4]
Radiation therapy may shrink the primary tumor but increase the number of CSCs

3.

Use the new CSC3™ device to isolate and capture CSCs

A Faster, Better, and Cheaper method to analyze CSCs

4.

Use Next Generation Sequencing (NGS) techniques on the CSCs to run Whole Genome Sequencing (WGS) which can identify each patients’ unique mutations

Personalized Medicine directly applied to a patients deadly CSCs

1. Zardavas et.al., “Emerging targeted agents for metastatic breast cancer”, Nature Reviews Clin. Oncol., Vol.10, April 2013, P.191-210, http://www.nature.com/nrclinonc/journal/v10/n4/full/nrclinonc.2013.29.html

2. Patsialou, A., et.al., “Selective gene-expression profiling of migratory tumor cels in vivo predicts clinical outcome in breast cancer patients”, Breast Cancer Research, Vol.14:R139, 2012, pp.1-19, http://breast-cancer-research.com/content/pdf/bcr3344.pdf

3. Liu, S., Wicha, M., “Targeting Breast Cancer Stem Cells”, J. Clin. Oncol., Vol. 28, 2010, pp.1-7, http://jco.ascopubs.org/content/28/25/4006.full.pdf+html

4. Liu, S., et.al., “Are Cancer Stem Cells Ready for Prime Time?”, The Scientist, Apr.1, 2012, http://www.the-scientist.com/?articles.view/articleNo/31887/title/Are-Cancer-Stem-Cells-Ready-for-Prime-Time-/